Al-Karamah SC (Arabic: نادي الكرامة الرياضي) is a Syrian professional football club based in the city of Homs. Founded in 1928, it is considered to be one of Asia's oldest sporting clubs. The club has won eight Syrian League titles and eight Syrian Cup titles. It also was the first Syrian club to win both the league and cup titles in the same year. The club is based at the Khaled Ibn Al Walid Stadium. In 2008 the club formed Board of Honor from a prominent business men of the city of Homs to support the club activities and Dr Mohammed Rahif Hakmi was elected as the board chairman.

The club covers other sports such as basketball, handball, table tennis, tennis and athletics for both, males and females. In addition to boxing, freestyle wrestling, judo, karate, weightlifting and cycling.